The microflora content in the intestinal biofilm may vary under the action of various factors. Medical intervention, including the instrumental or surgical interference, drug therapy may affect the biofilm integrity. If the influencing factors, which directly or indirectly act on holding, survival and functioning of the normal, accessory or random microflora, exceed the compensatory mechanisms of ecosystem protection, they will initiate the microbiological disturbances. They may cause the state referred to as the intestinal disbacteriosis. The term “disbacteriosis” was proposed by A. Nissle in 1916 to designate the putrefactive and carbohydrate intestinal dyspepsia.
Dysbiosis is the state of ecosystem whereby functioning of its components and mechanisms of their interaction becomes disturbed and causes the human disease progression. Dysbiosis is characteristic of the state of all groups of microorganisms, including bacteria, fungi, viruses, protozoa and helminths. Disbacteriosis reflects the state of bacterial forms of the microflora representatives.
Intestinal disbacteriosis is not a disease but a purely bacteriological definition characterizing the intestinal microbiocenosis disturbances in the qualitative composition and quantitative relationship.
In some cases the intestinal disbacteriosis become dominant in formation of the human pathological state and later may spontaneously cause a human disease.